Background: Brucellosis is one of the important multi-organ zoonotic infectious diseases. The forms of the CLINICAL course of brucellosis in humans are acute, sub-acute and chronic.Objectives: The present study aimed to retrospectively analyze the CLINICAL characteristics and complications in the CLINICAL forms of human brucellosis in Iran.Patients and Methods: The population included 957 patients admitted in the infectious diseases clinic affiliated to Babol University of Medical Sciences, Babol, Iran, within the past two decades. Data for the patients were obtained and documented in questionnaires.Patients were divided into three groups according to their history, symptoms and CLINICAL presentation time: acute (0 - 2 months), sub-acute (3 - 12 months), and chronic (> 1 year).Results: Most of the patients (73.8%) were in the acute stages of brucellosis, 22.6% had sub-acute brucellosis and 3.7% had chronic brucellosis. The most frequently observed symptoms were arthralgia (71%), sweating (66.7%), fever (57.2%) and backache (39.3%). The most common complication was arthritis (13.2%) in this study.Conclusions: This infection was observed with a diversity of CLINICAL manifestations. Therefore, diagnostic difficulty because of the various CLINICAL PRESENTATIONS and the way to find undiagnosed complications should be investigated in the differential diagnosis of other diseases.

Introduction: Tuberculosis (TB), with different types of respiratory tractinvolvements, has a high rate of mortality all around the world.Endobronchial involvement, which is a slightly common tuberculousinfection, requires special attention due to its severe complications such asbronchostenosis. Aim of study of this study was describes, one type ofpulmonary tuberculosis with less diagnosed and delayed treatment. Highsuspicious needs to diagnose and may be need bronchoscopy forconfirmed the diagnosis. It can be associated with sever complication andearly diagnosis and treatment are necessary for prevention of adverseeffect.Materials and Methods: This retrospective study was conducted in ateaching hospital during 2005-2010. Patients diagnosed withendobronchial tuberculosis through bronchoscopic biopsy were includedin the study. Diagnosis was confirmed by observation of caseous necrosis, bronchial lavage fluid or positive acid-fast staining in tissue samplesobtained through bronchial biopsy. Moreover, demographic information, endobronchial view, lab tests, as well as CLINICAL and radiographic findingswere reviewed and evaluated retrospectively.Results: A total of 20 cases were confirmed with endobronchial tuberculosis, 75% of whom were female with the mean age of 60 years. The results showedthat the most common CLINICAL symptom was cough (80%), the most commonfinding in the chest X-ray was consolidation (75%), and the most commonbronchoscopic feature was anthracosis (55%).Conclusion: TB is still a major concern, particularly in the developingcountries. Thus, in order for early diagnosis and prevention of this disease, we need to pay meticulous attention to its CLINICAL manifestations andbronchoscopic features.

Background: Since the Laryngeal polyp counts as one of the most prevalent laryngeal disorders which could burden the individual and society and lack of evidence with regard to its risk factors especially in Iran present study was carried out to determine Frequency and CLINICAL PRESENTATIONS of laryngeal polyps. Methods: In this cross-sectional analytic study, 150 patients diagnosed with laryngeal polyps who sought care at Emam Reza hospital of Tabriz from 1390 to 1396 were included. Collected data consisted of Age, Gender, Occupation, Living area, chief complaint, History of other diseases, history of vocal abuse, history of polyp in first degree relatives and habit history of patients. Results: Majority of participants (84. 7%) were male. Thirty percent of Laryngeal polyp were in fifth decade of life. Only 30 percent of individuals declared a history of vocal abuse at some point. Hoarseness was the main complaint and one-third of patients mentioned a history of GERD. One-third of them consumed cigarettes. Conclusion: Male Gender could increase the risk of developing laryngeal polyp. Age of 40-60 years and living in an urban setting could as well considered as a risk factor.

Introduction. Cytomegalovirus (CMV) infection is an important cause of morbidity and mortality in immunosuppressed patients. The ubiquity of this virus, its propensity to be reactivated when host defense is compromised. Its ability to disseminate to several organs help explain its frequent occurrence in the transplanted population. Numerous studies have shown that majority of the patients develop evidence of active CMV infection following kidney transplantation; however, the CLINICAL signs and symptoms are not frequently investigated.This study aimed at evaluating this issue. Methods. In a cross-sectional retrospective setting, 261 recipients of renal graft were reviewed in Tehran Hasheminejad Hospital between 2005 and 2006. The patients with CMV disease were recognized and studied separately. The CLINICAL and laboratory manifestations of the disease were determined and the frequencies were calculated.Results. Thirty-nine (14.9%) patients suffered from the CMV disease. The mean age of these patients was 42.28 ± 12.30 (range, 15 to 68 years) years, 26 (66.7%) were males and 13 (33.3%) were females. Three (7.7%) patients were serologically high-risk. Anti-rejection therapy was employed in 11 (28.2%) cases and prophylactic treatment with ganciclovir was prescribed in 5 (12.8%). The most frequent CLINICAL and laboratory manifestations were renal dysfunction (64.1%), anemia (61.5%), fever (56.4%), chills (33.3%), leukocytosis (23.1%), nausea, and vomiting (20.5%) and hepatic dysfunction (17.9%).Conclusion. Based on our results, almost one seventh of renal transplantations are complicated with CMV disease, with renal dysfunction as the most frequent symptom. These results are in conformity with the reports from similar centers. It is interesting that, in high risk serologic patients (D+/R-), symptoms and signs are nonspecific; such as nausea, anemia, and fever.

Castleman disease (CD) is a rare, lymphoproliferative disorder of uncertain etiology. We are reporting on two cases of Castleman disease. Both patients were female. This disease can be found wherever lymph nodes are present. We have reported two unusual cases of Castleman disease. A 29- year old woman was referred for evaluation because of a cervical lymph node, weight loss and night sweats. There was a history of Hodgkin’s disease. A 80- year old woman was referred to the oncology clinic because of progressive generalized pruritus and vertigo, weight loss, night sweats and fever. In two cases, a biopsy of the cervical lymph node revealed a plasma cell variant of Castleman disease.CD can present symptoms in patients. Therefore, CLINICAL, hematological and histological features of lymph node revealed a plasma cell variant which can be suggestive of Castleman disease.

Background: The incidence and prevalence of malignant nasopharyngeal cancers (NPC) are different in each part of the world. The prevalence of this malignancy is about 0. 5 in every 1000 people in the USA, while it is about 20 in every 100 people in China. this difference is due to nutritional, environmental, and genetic factors, especially for endemic regions. This malignancy is more common in men and is often seen in the sixth decade of life. We decided to do this study from the point of epidemiologic, CLINICAL, and radiologic findings in patients with nasopharyngeal cancers. Methods: This is a cross-sectional descriptive study of patients who were admitted to the ENT ward with the diagnosis of nasopharyngeal carcinoma from 2004 to 2014. Thirty-two patients were studied from the point of age, gender, risk factors, CLINICAL and radiologic findings. Results: Of 32 patients, 26 patients (%81) were male, and six patients (%19) were female. The mean age of the patients was 50. 28 years old. Nineteen patients were self-employed, 4 were farmers, 3 were staffers, and 6 were house worker women. %84 of the patients had a negative family history of nasopharyngeal carcinoma. %66 of the patients had neck mass, and the second most common CLINICAL finding was nasal obstruction. The most common site of tumor origin was the right lateral wall (%37), and the second was the left lateral wall (%28). Eight patients had erosion of the skull base, and 14 patients had tumor expansion to the paranasal sinuses and orbital cavity. Conclusion: In patients complaining of a neck mass, nasal obstruction, and headache, nasopharyngeal cancer should be highly suspected. Nasal endoscopy and biopsy of the suspected lesion are needed for correct diagnosis and treatment

Dear Editor, Cystic Fibrosis (CF), characterized by abnormal transport of chloride and sodium ion across the epithelium, leads to thick, viscous secretions. The hallmark signs and symptoms of cystic fibrosis are salty tasting skin, poor growth and poor weight gain despite a normal food intake, accumulation of thick, sticky mucus, frequent chest infections, and coughing or shortness of breath.

Background: Head and neck cancer is the sixth most common malignancy worldwide. Neoplastic lymphoma is a malignant origin of colonization of B cell, T cell and NK cell. It is the third most common malignancy in the head and neck area after squamous cell carcinoma and salivary gland tumors. Lymphoma is divided into Non Hodgkin's lymphoma (NHL) and Hodgkin lymphoma (HL) groups. They have two peak ages of 20-30 and 70-60 years. The first symptom of lymphoma in patients is usually a painless, enlarging lymph node. Then we can mention weight loss, night sweats, fever. Diagnosis is based on CLINICAL findings and biopsy. The aim of this study was to determine the frequency and histopathologic subtypes of the head and neck lymphomas and to evaluate the CLINICAL symptoms and diagnostic processes in patients with lymphoma diagnosed in ENT department of East Azerbaijan University of Medical Sciences. Methods: The study population has 40 samples. There were 602 seropositive biopsies and 59 patients with diagnosed lymphoma, 19 of which were excluded due to lack of records and exclusion criteria. Patients' records were reviewed for age, sex, CLINICAL presentation, laboratory tests, Paraclinic and pathologic outcome. Results: The Hodgkin's lymphoma was 62. 5% more common than non Hodgkin's lymphoma. Most patients were in the age range of 10-20 years. Mean age of patients was 35. 6 ± 24 24. 72. 82. 5% of patients referred to the hospital with complaints of neck swelling. The most prevalent subtype of Hodgkin's lymphoma was nodular sclerosis (44%) and the most prevalent subtype of non Hodgkin's was diffuse large B cell 36%. Conclusion: lymphoma should be considered as one of the differential diagnoses of cervical swelling in the diagnostic and therapeutic studies of patients. Also, males and age groups of 10-20 years and 60-70 years should be considered important.